The Nutritional Intervention of Resveratrol Can Effectively Alleviate the Intestinal Inflammation Associated With Celiac Disease Induced by Wheat Gluten
Background and AimsWheat gluten is a critical trigger for celiac disease, often causing inflammatory lesions and oxidative stress damage in the intestines of patients. In daily life, it is difficult for celiac disease patients to strictly avoid the dietary intake of gluten, which makes complementary...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.878186/full |
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| author | Tian Yu Tian Yu Tian Yu Yiting Xie Yiting Xie Yiting Xie Juanli Yuan Juanli Yuan Jinyan Gao Zhiwen Xiao Zhiwen Xiao Zhiwen Xiao Yong Wu Yong Wu Hongbing Chen Hongbing Chen |
| author_facet | Tian Yu Tian Yu Tian Yu Yiting Xie Yiting Xie Yiting Xie Juanli Yuan Juanli Yuan Jinyan Gao Zhiwen Xiao Zhiwen Xiao Zhiwen Xiao Yong Wu Yong Wu Hongbing Chen Hongbing Chen |
| author_sort | Tian Yu |
| collection | DOAJ |
| description | Background and AimsWheat gluten is a critical trigger for celiac disease, often causing inflammatory lesions and oxidative stress damage in the intestines of patients. In daily life, it is difficult for celiac disease patients to strictly avoid the dietary intake of gluten, which makes complementary preventive therapy particularly urgent. As such, we investigated the alleviating effects of resveratrol in vivo and in vitro models of celiac disease.MethodsWe established in vivo and in vitro models of gluten protein-induced celiac disease. The intervention effect of resveratrol was defined well based on relevant indicators of inflammation, immunity and oxidative stress, and its possible involvement in signaling pathways and genes were also identified.ResultsResveratrol was effective in reducing intestinal oxidative stress and inflammatory damage induced by wheat gluten in both cell and mouse models for celiac disease. We identified correlations between the genes (Fgf15, Nr0b2, Aire and Ubd) and signaling pathways (PPAR, AMPK and FoxO) in which resveratrol performed critical roles.ConclusionsResveratrol contributed to regulate development of autoimmunity through up-regulation of Aire and Ubd genes and promote nutrient absorption in intestine through down-regulation of Fgf15 and Nr0b2 genes, as well as played a role in regulating complex response system of oxidative stress, inflammatory response and immune response in intestine by activating PPAR, AMPK and FoxO signaling pathways, thus effectively alleviating the intestinal symptoms of celiac disease. |
| first_indexed | 2024-04-13T06:09:48Z |
| format | Article |
| id | doaj.art-6fcfff8d6a2147f0a4a3eab872f631ee |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T06:09:48Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6fcfff8d6a2147f0a4a3eab872f631ee2022-12-22T02:59:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-04-011310.3389/fimmu.2022.878186878186The Nutritional Intervention of Resveratrol Can Effectively Alleviate the Intestinal Inflammation Associated With Celiac Disease Induced by Wheat GlutenTian Yu0Tian Yu1Tian Yu2Yiting Xie3Yiting Xie4Yiting Xie5Juanli Yuan6Juanli Yuan7Jinyan Gao8Zhiwen Xiao9Zhiwen Xiao10Zhiwen Xiao11Yong Wu12Yong Wu13Hongbing Chen14Hongbing Chen15State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, ChinaSino-German Joint Research Institute, Nanchang University, Nanchang, ChinaSchool of Food Science and Technology, Nanchang University, Nanchang, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, ChinaSino-German Joint Research Institute, Nanchang University, Nanchang, ChinaSchool of Food Science and Technology, Nanchang University, Nanchang, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, ChinaSchool of Pharmaceutical Science, Nanchang University, Nanchang, ChinaSchool of Food Science and Technology, Nanchang University, Nanchang, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, ChinaSino-German Joint Research Institute, Nanchang University, Nanchang, ChinaSchool of Food Science and Technology, Nanchang University, Nanchang, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, ChinaSino-German Joint Research Institute, Nanchang University, Nanchang, ChinaState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, ChinaSino-German Joint Research Institute, Nanchang University, Nanchang, ChinaBackground and AimsWheat gluten is a critical trigger for celiac disease, often causing inflammatory lesions and oxidative stress damage in the intestines of patients. In daily life, it is difficult for celiac disease patients to strictly avoid the dietary intake of gluten, which makes complementary preventive therapy particularly urgent. As such, we investigated the alleviating effects of resveratrol in vivo and in vitro models of celiac disease.MethodsWe established in vivo and in vitro models of gluten protein-induced celiac disease. The intervention effect of resveratrol was defined well based on relevant indicators of inflammation, immunity and oxidative stress, and its possible involvement in signaling pathways and genes were also identified.ResultsResveratrol was effective in reducing intestinal oxidative stress and inflammatory damage induced by wheat gluten in both cell and mouse models for celiac disease. We identified correlations between the genes (Fgf15, Nr0b2, Aire and Ubd) and signaling pathways (PPAR, AMPK and FoxO) in which resveratrol performed critical roles.ConclusionsResveratrol contributed to regulate development of autoimmunity through up-regulation of Aire and Ubd genes and promote nutrient absorption in intestine through down-regulation of Fgf15 and Nr0b2 genes, as well as played a role in regulating complex response system of oxidative stress, inflammatory response and immune response in intestine by activating PPAR, AMPK and FoxO signaling pathways, thus effectively alleviating the intestinal symptoms of celiac disease.https://www.frontiersin.org/articles/10.3389/fimmu.2022.878186/fullceliac diseasegliadinintestinal inflammationoxidative damageresveratrolnutritional intervention |
| spellingShingle | Tian Yu Tian Yu Tian Yu Yiting Xie Yiting Xie Yiting Xie Juanli Yuan Juanli Yuan Jinyan Gao Zhiwen Xiao Zhiwen Xiao Zhiwen Xiao Yong Wu Yong Wu Hongbing Chen Hongbing Chen The Nutritional Intervention of Resveratrol Can Effectively Alleviate the Intestinal Inflammation Associated With Celiac Disease Induced by Wheat Gluten Frontiers in Immunology celiac disease gliadin intestinal inflammation oxidative damage resveratrol nutritional intervention |
| title | The Nutritional Intervention of Resveratrol Can Effectively Alleviate the Intestinal Inflammation Associated With Celiac Disease Induced by Wheat Gluten |
| title_full | The Nutritional Intervention of Resveratrol Can Effectively Alleviate the Intestinal Inflammation Associated With Celiac Disease Induced by Wheat Gluten |
| title_fullStr | The Nutritional Intervention of Resveratrol Can Effectively Alleviate the Intestinal Inflammation Associated With Celiac Disease Induced by Wheat Gluten |
| title_full_unstemmed | The Nutritional Intervention of Resveratrol Can Effectively Alleviate the Intestinal Inflammation Associated With Celiac Disease Induced by Wheat Gluten |
| title_short | The Nutritional Intervention of Resveratrol Can Effectively Alleviate the Intestinal Inflammation Associated With Celiac Disease Induced by Wheat Gluten |
| title_sort | nutritional intervention of resveratrol can effectively alleviate the intestinal inflammation associated with celiac disease induced by wheat gluten |
| topic | celiac disease gliadin intestinal inflammation oxidative damage resveratrol nutritional intervention |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.878186/full |
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