Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation

Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation

Repressor protein period (PER) complexes play a central role in the molecular oscillator mechanism of the mammalian circadian clock. While the main role of nuclear PER complexes is transcriptional repression, much less is known about the functions of cytoplasmic PER complexes. We found with a bioche...

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Bibliographic Details
Main Authors: Hussam Ibrahim, Philipp Reus, Anna Katharina Mundorf, Anna-Lena Grothoff, Valerie Rudenko, Christina Buschhaus, Anja Stefanski, Niklas Berleth, Björn Stork, Kai Stühler, Faiza Kalfalah, Hans Reinke
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
circadian clock
PER complex
GAPVD1
protein phosphorylation
protein degradation
Online Access:https://www.mdpi.com/1422-0067/22/7/3787

Internet

https://www.mdpi.com/1422-0067/22/7/3787

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