Integration of ATAC-Seq and RNA-Seq identifies key genes and pathways involved in the neuroprotection of S-adenosylmethionine against perioperative neurocognitive disorder

Integration of ATAC-Seq and RNA-Seq identifies key genes and pathways involved in the neuroprotection of S-adenosylmethionine against perioperative neurocognitive disorder

The gene-regulatory landscape is highly dynamic in healthy and diseased brains. DNA methylation is a well-known epigenetic modification that regulates gene expression, and our previous study demonstrated that S-adenosylmethionine (SAM), a methylome modulator, was a neuroprotectant against perioperat...

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Bibliographic Details
Main Authors: Feifei Xu, Peilin Cong, Zhihong Lu, Liwen Shi, Lize Xiong, Guanghou Zhao
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Perioperative neurocognitive disorder
SAM
Gene expression
Chromatin accessibility
Transcription factor
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023000995

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http://www.sciencedirect.com/science/article/pii/S2001037023000995

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