Inflammation versus regulation: how interferon-gamma contributes to type 1 diabetes pathogenesis

Inflammation versus regulation: how interferon-gamma contributes to type 1 diabetes pathogenesis

Type 1 diabetes is an autoimmune disease with onset from early childhood. The insulin-producing pancreatic beta cells are destroyed by CD8+ cytotoxic T cells. The disease is challenging to study mechanistically in humans because it is not possible to biopsy the pancreatic islets and the disease is m...

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Bibliographic Details
Main Authors: David J. De George, Tingting Ge, Balasubramaniam Krishnamurthy, Thomas W. H. Kay, Helen E. Thomas
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
type 1 daibetes mellitus
interferon gamma (IFNγ)
CD8 T cells
inflammation
autoimmunity
T cell proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1205590/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1205590/full

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