Inflammation versus regulation: how interferon-gamma contributes to type 1 diabetes pathogenesis
Type 1 diabetes is an autoimmune disease with onset from early childhood. The insulin-producing pancreatic beta cells are destroyed by CD8+ cytotoxic T cells. The disease is challenging to study mechanistically in humans because it is not possible to biopsy the pancreatic islets and the disease is m...
Main Authors: | David J. De George, Tingting Ge, Balasubramaniam Krishnamurthy, Thomas W. H. Kay, Helen E. Thomas |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-05-01
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Series: | Frontiers in Cell and Developmental Biology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1205590/full |
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