Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways

Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways

ABSTRACT Regulation of epidermal growth factor (EGF) receptor (EGFR) signaling is critical for the replication of human cytomegalovirus (HCMV) as well as latency and reactivation in CD34+ hematopoietic progenitor cells. HCMV microRNAs (miRNAs) provide a means to modulate the signaling activated by E...

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Bibliographic Details
Main Authors: Meaghan H. Hancock, Jennifer Mitchell, Felicia D. Goodrum, Jay A. Nelson
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mSphere
Subjects:
GAB1
UL138
cytomegalovirus
miRNA
Online Access:https://journals.asm.org/doi/10.1128/msphere.00582-20

Internet

https://journals.asm.org/doi/10.1128/msphere.00582-20

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