Safety and efficacy of human juvenile chondrocyte-derived cell sheets for osteochondral defect treatment

Abstract Knee cartilage does not regenerate spontaneously after injury, and a gold standard regenerative treatment algorithm has not been established. This study demonstrates preclinical safety and efficacy of scaffold-free, human juvenile cartilage-derived-chondrocyte (JCC) sheets produced from rou...

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Bibliographic Details
Main Authors: Makoto Kondo, Sumako Kameishi, Kyungsook Kim, Nicolas F. Metzler, Travis G. Maak, Douglas T. Hutchinson, Angela A. Wang, Miki Maehara, Masato Sato, David W. Grainger, Teruo Okano
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-021-00173-9