The Radical SAM Heme Synthase AhbD from <i>Methanosarcina barkeri</i> Contains Two Auxiliary [4Fe-4S] Clusters

In archaea and sulfate-reducing bacteria, heme is synthesized via the siroheme-dependent pathway. The last step of this route is catalyzed by the Radical SAM enzyme AhbD and consists of the conversion of iron-coproporphyrin III into heme. AhbD belongs to the subfamily of Radical SAM enzymes containi...

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Bibliographic Details
Main Authors: Isabelle Fix, Lorenz Heidinger, Thorsten Friedrich, Gunhild Layer
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/13/8/1268