Rational design of a new mutant of tobacco etch virus protease in order to increase the in vitro solubility

Background and purpose: Tobacco etch virus (TEV) protease is a protease with high sequence specificity which is useful for the cleavage of fusion proteins. A major limitation of this enzyme is its relatively poor solubility. This study aimed to investigate the effects of some suggested mutations by...

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Bibliographic Details
Main Authors: Hossein Mohammadian, Karim Mahnam, Hamid Mirmohammad Sadeghi, Mohamad Reza Ganjalikhany, Vajihe Akbari
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2020;volume=15;issue=2;spage=164;epage=173;aulast=Mohammadian