Halogen doped graphene quantum dots modulate TDP-43 phase separation and aggregation in the nucleus

Halogen doped graphene quantum dots modulate TDP-43 phase separation and aggregation in the nucleus

Abstract TDP-43 is implicated in the dynamic formation of nuclear bodies and stress granules through phase separation. In diseased states, it can further condense into pathological aggregates in the nucleus and cytoplasm, contributing to the onset of amyotrophic lateral sclerosis. In this study, we...

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Bibliographic Details
Main Authors: Hong Zhang, Huazhang Guo, Danni Li, Yiling Zhang, Shengnan Zhang, Wenyan Kang, Cong Liu, Weidong Le, Liang Wang, Dan Li, Bin Dai
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47167-x

Internet

https://doi.org/10.1038/s41467-024-47167-x

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