Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala

Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala

The presynaptic protein α-synuclein (αSyn) has been suggested to be involved in the pathogenesis of Parkinson’s disease (PD). In PD, the amygdala is prone to develop insoluble αSyn aggregates, and it has been suggested that circuit dysfunction involving the amygdala contributes to the psychiatric sy...

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Bibliographic Details
Main Authors: Liqiang Chen, Chetan Nagaraja, Samuel Daniels, Zoe A Fisk, Rachel Dvorak, Lindsay Meyerdirk, Jennifer A Steiner, Martha L Escobar Galvis, Michael X Henderson, Maxime WC Rousseaux, Patrik Brundin, Hong-Yuan Chu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-07-01
Series:eLife
Subjects:
alpha-synuclein
amygdala
vGlut
synapse
parkinson's disease
synucleinopathies
Online Access:https://elifesciences.org/articles/78055

Internet

https://elifesciences.org/articles/78055

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