Lower Levels of GABAergic Function Markers in Corticotropin-Releasing Hormone-Expressing Neurons in the sgACC of Human Subjects With Depression

Lower Levels of GABAergic Function Markers in Corticotropin-Releasing Hormone-Expressing Neurons in the sgACC of Human Subjects With Depression

RationaleA previous transcriptome meta-analysis revealed significantly lower levels of corticotropin-releasing hormone (CRH) mRNA in corticolimbic brain regions in major depressive disorder (MDD) subjects, suggesting that cortical CRH-expressing (CRH+) cells are affected in MDD. Rodent studies show...

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Bibliographic Details
Main Authors: Hyunjung Oh, Dwight Newton, David Lewis, Etienne Sibille
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Psychiatry
Subjects:
MDD (major depressive disorder)
CRH
cell dysfunction
GABA
sgACC
human post mortem tissue
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.827972/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2022.827972/full

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