Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches

Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches

Microtubule affinity regulating kinase 4 (MARK4) regulates the mechanism of microtubules by its ability to phosphorylate the microtubule-associated proteins (MAP’s). MARK4 is known for its major role in tau phosphorylation via phosphorylating Ser<sup>262</sup> residue in the KXGS motif,...

Full description

Bibliographic Details
Main Authors: Ghulam Md. Ashraf, Debarati DasGupta, Mohammad Zubair Alam, Saleh S. Baeesa, Badrah S. Alghamdi, Firoz Anwar, Thamer M. A. Alqurashi, Sharaf E. Sharaf, Waleed Al Abdulmonem, Mohammed A. Alyousef, Fahad A. Alhumaydhi, Anas Shamsi
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
MARK4
drug repurposing
drug discovery
virtual screening
molecular docking
MD simulation
Online Access:https://www.mdpi.com/1420-3049/27/14/4652

Internet

https://www.mdpi.com/1420-3049/27/14/4652

Similar Items