Mitochondrial Dysfunction in Heart Failure: From Pathophysiological Mechanisms to Therapeutic Opportunities

Mitochondrial Dysfunction in Heart Failure: From Pathophysiological Mechanisms to Therapeutic Opportunities

Mitochondrial dysfunction, a feature of heart failure, leads to a progressive decline in bioenergetic reserve capacity, consisting in a shift of energy production from mitochondrial fatty acid oxidation to glycolytic pathways. This adaptive process of cardiomyocytes does not represent an effective s...

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Bibliographic Details
Main Authors: Giovanna Gallo, Speranza Rubattu, Massimo Volpe
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria
electron transport chain
oxidative stress
inflammation
heart failure
cardiac disease
Online Access:https://www.mdpi.com/1422-0067/25/5/2667

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https://www.mdpi.com/1422-0067/25/5/2667

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