Conversion of Osteoclasts into Bone-Protective, Tumor-Suppressing Cells

Osteoclasts are a driver of a vicious bone-destructive cycle with breast cancer cells. Here, we examined whether this vicious cycle can be altered into a beneficial one by activating Wnt signaling with its activating agent, BML284. The conditioned medium, derived from Wnt-activated RAW264.7 pre-oste...

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Bibliographic Details
Main Authors: Ke-Xin Li, Xun Sun, Bai-Yan Li, Hiroki Yokota
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/13/22/5593