A stereoselective approach to the angucyclinone antibiotics: A total synthesis of (±)-urdamycinone B
A stereoselective chiral Lewis acid promoted reaction of siloxydiene (±)-13 and dienophile complex 18, gave a 4:1 mixture of urdamycinone B (1) and its C-3 epimer (24) in several steps in 12% overall yield. Separation of these products was achieved by high performance liquid chromatography (HPLC). K...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-12-01
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| Series: | Arabian Journal of Chemistry |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535215001240 |