Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations

Single-cell RNA-seq of out-of-thaw mesenchymal stromal cells shows tissue-of-origin differences and inter-donor cell-cycle variations

Abstract Background Human Mesenchymal stromal cells (hMSCs) from various tissue sources are widely investigated in clinical trials. These MSCs are often administered to patients immediately after thawing the cryopreserved product (out-of-thaw), yet little is known about the single-cell transcriptomi...

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Bibliographic Details
Main Authors: Camila Medrano-Trochez, Paramita Chatterjee, Pallab Pradhan, Hazel Y. Stevens, Molly E. Ogle, Edward A. Botchwey, Joanne Kurtzberg, Carolyn Yeago, Greg Gibson, Krishnendu Roy
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Stem Cell Research & Therapy
Subjects:
MSC
Cell therapy
Bone marrow derived MSC (BM-MSC)
Cord tissue derived MSC (CT-MSC)
scRNA-seq
Online Access:https://doi.org/10.1186/s13287-021-02627-9

Internet

https://doi.org/10.1186/s13287-021-02627-9

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