Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration

Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration

Abstract Vascular endothelial protein tyrosine phosphatase (VE‐PTP) influences endothelial barrier function by regulating the activation of tyrosine kinase receptor Tie2. We determined whether this action is linked to the development of atherosclerosis by examining the influence of arterial shear st...

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Bibliographic Details
Main Authors: Keisuke Shirakura, Peter Baluk, Astrid F Nottebaum, Ute Ipe, Kevin G Peters, Donald M McDonald, Dietmar Vestweber
Format: Article
Language:English
Published: Springer Nature 2023-04-01
Series:EMBO Molecular Medicine
Subjects:
aorta
atherosclerosis
endothelial junctions
laminar flow
vascular leakage
Online Access:https://doi.org/10.15252/emmm.202216128

Internet

https://doi.org/10.15252/emmm.202216128

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