The impact of TLR2 and aging on the humoral immune response to Staphylococcus aureus bacteremia in mice

The impact of TLR2 and aging on the humoral immune response to Staphylococcus aureus bacteremia in mice

Abstract Aging alters immunoglobulin production, affecting the humoral immune response. Toll-like receptor 2 (TLR2) recognizes Staphylococcus aureus (S. aureus) which causes bacteremia with high mortality in the elderly. To understand how TLR2 and aging affect the humoral immune response in bacterem...

Full description

Bibliographic Details
Main Authors:	Priti Gupta, Zhicheng Hu, Pradeep Kumar Kopparapu, Meghshree Deshmukh, Tibor Sághy, Majd Mohammad, Tao Jin, Cecilia Engdahl
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-05-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-023-35970-3

Similar Items

Lipoproteins Are Responsible for the Pro-Inflammatory Property of <i>Staphylococcus aureus</i> Extracellular Vesicles
by: Pradeep Kumar Kopparapu, et al.
Published: (2021-07-01)

Gene expression of S100a8/a9 predicts Staphylococcus aureus-induced septic arthritis in mice
by: Meghshree Deshmukh, et al.
Published: (2023-06-01)

Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy postmenopause
by: Priti Gupta, et al.
Published: (2023-09-01)

Humoral immune consequences of Staphylococcus aureus ST239-associated bacteremia
by: H. Ghasemzadeh, Moghaddam, et al.
Published: (2018)

Characterization of the humoral immune response during Staphylococcus aureus bacteremia and global gene expression by Staphylococcus aureus in human blood.
by: Paul Martijn den Reijer, et al.
Published: (2013-01-01)

Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing
by: Majd Mohammad, et al.
Published: (2021-03-01)

Staphylococcus aureus Bacteremia, Europe
by: Edine W. Tiemersma, et al.
Published: (2005-11-01)

Staphylococcus aureus Bacteremia, Australia
by: Peter Collignon, et al.
Published: (2005-04-01)

Predictors of infectious foci on FDG PET/CT in Staphylococcus aureus bacteremia
by: Nesrin Ghanem-Zoubi, et al.
Published: (2023-08-01)

Antiplatelet therapy for Staphylococcus aureus bacteremia: Will it stick?
by: Alexander M Tatara, et al.
Published: (2022-02-01)

Epidemiology of Community-Onset Staphylococcus aureus Bacteremia
by: James Y. Yarovoy, et al.
Published: (2019-04-01)

The YIN and YANG of lipoproteins in developing and preventing infectious arthritis by Staphylococcus aureus.
by: Majd Mohammad, et al.
Published: (2019-06-01)

Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice.
by: Sanne van den Berg, et al.
Published: (2013-01-01)

Primary iliopsoas abscess due to Staphylococcus aureus bacteremia
by: Chee Yik Chang, et al.
Published: (2020-11-01)

TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia.
by: Tobias Strunk, et al.
Published: (2010-04-01)

Active immunization with an octa-valent Staphylococcus aureus antigen mixture in models of S. aureus bacteremia and skin infection in mice.
by: Sanne van den Berg, et al.
Published: (2015-01-01)

<it>Staphylococcus aureus </it>bacteriuria as a prognosticator for outcome of <it>Staphylococcus aureus </it>bacteremia: a case-control study
by: Weinstein Robert A, et al.
Published: (2010-07-01)

Staphylococcus aureus bacteremia in patients with prosthetic devices: costs and outcomes.
by: Chu, V, et al.
Published: (2005)

Prognostic significance of early platelet dynamics in Staphylococcus aureus bacteremia
by: Rachid Douglas-Louis, et al.
Published: (2023-02-01)

Staphylococcus aureus bacteremia: what is the impact of oxacillin resistance on mortality?
by: V.C. Cassettari, et al.

Clinical reasoning for performance of transesophageal echocardiography in veterans with Staphylococcus aureus bacteremia
by: Emily C. Woods, et al.
Published: (2023-01-01)

Staphylococcus aureus Bacteremia with Multiple Metastatic Abscesses in a Diabetic Patient
by: Derya SEYMAN, et al.
Published: (2004-06-01)

Staphylococcus aureus Bacteremia in Children of Rural Areas of The Gambia, 2008–2015
by: Aderonke Odutola, et al.
Published: (2019-04-01)

Genetic variability in beta-defensins is not associated with susceptibility to Staphylococcus aureus bacteremia.
by: Peder Fode, et al.
Published: (2012-01-01)

Genomic evolution of Staphylococcus aureus isolates colonizing the nares and progressing to bacteremia.
by: Jeanne B Benoit, et al.
Published: (2018-01-01)

High Vancomycin MIC and Complicated Methicillin-Susceptible Staphylococcus aureus Bacteremia
by: Jose Maria Aguado, et al.
Published: (2011-06-01)

Phenol-soluble modulin α and β display divergent roles in mice with staphylococcal septic arthritis
by: Zhicheng Hu, et al.
Published: (2022-09-01)

Factors for mortality in patients with persistent Staphylococcus aureus bacteremia: The importance of treatment response rather than bacteremia duration
by: Si-Ho Kim, et al.
Published: (2023-10-01)

High hospital incidence of Staphylococcus aureus bacteremia in young infants in the Lao PDR
by: Luangxay, K, et al.
Published: (2012)

Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia.
by: Fowler, V, et al.
Published: (2005)

Factors associated with foreign body infection in methicillin-resistant Staphylococcus aureus bacteremia
by: Kevin Bouiller, et al.
Published: (2024-02-01)

A Population-Based Evaluation of Polymicrobial <i>Staphylococcus aureus</i> Bacteremia
by: Joya-Rita Hindy, et al.
Published: (2022-12-01)

BACTEREMIA POR STAPHYLOCOCCUS AUREUS EM UNIDADE CARDIOLÓGICA: CARACTERÍSTICAS E DESFECHOS
by: Manuela da Costa Medeiros, et al.
Published: (2023-10-01)

Methicillin-resistant Staphylococcus aureus bacteremia with elevated vancomycin minimum inhibitory concentrations
by: Alexandra G. Mills, et al.
Published: (2023-01-01)

The Use of Daptomycin and Quinolones Combination in Staphylococcus aureus Bacteremia: An In Vitro Synergistic Study
by: Derya KETEN, et al.
Published: (2013-09-01)

Bacterial DNA load in Staphylococcus aureus bacteremia is significantly higher in intravascular infections.
by: An-Emmie Nieman, et al.
Published: (2022-01-01)

Relationship between mortality and molecular epidemiology of methicillin-resistant Staphylococcus aureus bacteremia.
by: Masaru Shimizu, et al.
Published: (2022-01-01)

Age-Dependent Increase in Incidence of Staphylococcus aureus Bacteremia, Denmark, 2008–2015
by: Louise Thorlacius-Ussing, et al.
Published: (2019-05-01)

Decreased quality of care for Staphylococcus aureus bacteremia during the COVID-19 pandemic
by: Simona Arientová, et al.
Published: (2022-07-01)

Staphylococcus aureus bacteremia: comparison of two periods and a predictive model of mortality
by: Lucieni de Oliveira Conterno, et al.