Tau truncation in the pathogenesis of Alzheimer’s disease: a narrative review

Tau truncation in the pathogenesis of Alzheimer’s disease: a narrative review

Alzheimer’s disease is characterized by two major neuropathological hallmarks—the extracellular β-amyloid plaques and intracellular neurofibrillary tangles consisting of aggregated and hyperphosphorylated Tau protein. Recent studies suggest that dysregulation of the microtubule-associated protein Ta...

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Bibliographic Details
Main Authors: Dandan Chu, Xingyue Yang, Jing Wang, Yan Zhou, Jin-Hua Gu, Jin Miao, Feng Wu, Fei Liu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-01-01
Series:Neural Regeneration Research
Subjects:
alzheimer’s disease; cleavage site; diagnosis; marker; neurofibrillary tangles; phosphorylation; tau; tau aggregation; therapy; truncation
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=6;spage=1221;epage=1232;aulast=Chu

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2024;volume=19;issue=6;spage=1221;epage=1232;aulast=Chu

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