Zinc oxide nanoparticles inhibit osteosarcoma metastasis by downregulating β-catenin via HIF-1α/BNIP3/LC3B-mediated mitophagy pathway

Zinc oxide nanoparticles inhibit osteosarcoma metastasis by downregulating β-catenin via HIF-1α/BNIP3/LC3B-mediated mitophagy pathway

Osteosarcoma (OS) therapy faces many challenges, especially the poor survival rate once metastasis occurs. Therefore, it is crucial to explore new OS treatment strategies that can efficiently inhibit OS metastasis. Bioactive nanoparticles such as zinc oxide nanoparticles (ZnO NPs) can efficiently in...

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Bibliographic Details
Main Authors: Guanping He, Jing-Jun Nie, Xiao Liu, Zihao Ding, Peng Luo, Yu Liu, Bo-Wen Zhang, Renxian Wang, Xiaoguang Liu, Yong Hai, Da-Fu Chen
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-01-01
Series:Bioactive Materials
Subjects:
Zinc oxide nanoparticle
HIF-1α/BNIP3/LC3B-mediated mitophagy pathway
Metastasis
Osteosarcoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22002171

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http://www.sciencedirect.com/science/article/pii/S2452199X22002171

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