Graph construction method impacts variation representation and analyses in a bovine super-pangenome

Graph construction method impacts variation representation and analyses in a bovine super-pangenome

Abstract Background Several models and algorithms have been proposed to build pangenomes from multiple input assemblies, but their impact on variant representation, and consequently downstream analyses, is largely unknown. Results We create multi-species super-pangenomes using pggb, cactus, and mini...

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Bibliographic Details
Main Authors: Alexander S. Leonard, Danang Crysnanto, Xena M. Mapel, Meenu Bhati, Hubert Pausch
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Genome Biology
Subjects:
Bovinae
Graph pangenome
Long sequencing reads
Genome assembly
Structural variation
Domestic animals
Online Access:https://doi.org/10.1186/s13059-023-02969-y

Internet

https://doi.org/10.1186/s13059-023-02969-y

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