Genetic Silencing of Fatty Acid Desaturases Modulates α-Synuclein Toxicity and Neuronal Loss in Parkinson-Like Models of C. elegans

Genetic Silencing of Fatty Acid Desaturases Modulates α-Synuclein Toxicity and Neuronal Loss in Parkinson-Like Models of C. elegans

The molecular basis of Parkinson’s disease (PD) is currently unknown. There is increasing evidence that fat metabolism is at the crossroad of key molecular pathways associated with the pathophysiology of PD. Fatty acid desaturases catalyze synthesis of saturated fatty acids from monounsaturated fatt...

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Chi tiết về thư mục
Những tác giả chính: Malabika Maulik, Swarup Mitra, Ajiel Mae Basmayor, Brianna Lu, Barbara E. Taylor, Abel Bult-Ito
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Frontiers Media S.A. 2019-08-01
Loạt:Frontiers in Aging Neuroscience
Những chủ đề:
C. elegans
fat
Parkinson’s disease
Δ9 desaturase
α-synuclein
dopamine
Truy cập trực tuyến:https://www.frontiersin.org/article/10.3389/fnagi.2019.00207/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00207/full

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