Characterization of clonal immunoglobulin heavy V-D-J gene rearrangements in Chinese patients with chronic lymphocytic leukemia: Clinical features and molecular profiles

Characterization of clonal immunoglobulin heavy V-D-J gene rearrangements in Chinese patients with chronic lymphocytic leukemia: Clinical features and molecular profiles

IntroductionSeveral prognostic factors of chronic lymphocytic leukemia (CLL) have been identified, such as cytogenetic aberrations and recurrent gene mutations. B-cell receptor (BCR) signaling plays an important role in the tumorigenesis of CLL, and its clinical significance in predicting prognosis...

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Bibliographic Details
Main Authors: Xinyue Deng, Meilan Zhang, Jiachen Wang, Xiaoxi Zhou, Min Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Oncology
Subjects:
chronic lymphocytic leukemia
B-cell receptor
gene mutation
prognostic factors
next generation (deep) sequencing (NGS)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1120867/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1120867/full

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