Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production

Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production

Objective: FAS-mediated apoptosis of hepatocytes and aberrant TGF-β signaling are major drivers of liver fibrosis. Decreased miRNA let-7 expression in the livers of patients and animals with fibrosis suggests a mechanistic link of let-7 to hepatic fibrogenesis. Methods: Using transient transfection...

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Bibliographic Details
Main Authors: Jiahui Song, Haining Lv, Beibei Liu, Mingjun Hao, Hugh S. Taylor, Xuchen Zhang, Da Li, Yingqun Huang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Metabolism
Subjects:
Fibrosis
Let-7
Apoptosis
Gene therapy
Liver
AAV
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782300162X

Internet

http://www.sciencedirect.com/science/article/pii/S221287782300162X

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