Tracking Topological and Electronic Effects on the Folding and Stability of Guanine-Deficient RNA G-Quadruplexes, Engineered with a New Computational Tool for De Novo Quadruplex Folding

Tracking Topological and Electronic Effects on the Folding and Stability of Guanine-Deficient RNA G-Quadruplexes, Engineered with a New Computational Tool for De Novo Quadruplex Folding

The initial aim of this work was to elucidate the mutual influence of different single-stranded segments (loops and caps) on the thermodynamic stability of RNA G-quadruplexes. To this end, we used a new NAB-GQ-builder software program, to construct dozens of two-tetrad G-quadruplex topologies, based...

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Bibliographic Details
Main Authors: Yavuz Burak Göç, Jakub Poziemski, Weronika Smolińska, Dominik Suwała, Grzegorz Wieczorek, Dorota Niedzialek
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
RNA G-quadruplex folding
RNA—cation interactions
valence tautomerism
de novo RNA modelling
RNA G-quadruplex stabilization
Online Access:https://www.mdpi.com/1422-0067/23/19/10990

Internet

https://www.mdpi.com/1422-0067/23/19/10990

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