Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer’s disease

Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer’s disease

Abstract Background The progressive development of Alzheimer’s disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connecte...

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Bibliographic Details
Main Authors: Sonia George, Annica Rönnbäck, Gunnar K Gouras, Géraldine H Petit, Fiona Grueninger, Bengt Winblad, Caroline Graff, Patrik Brundin
Format: Article
Language:English
Published: BMC 2014-02-01
Series:Acta Neuropathologica Communications
Subjects:
Amyloid-β
Alzheimer’s disease
Subiculum
Transgenic APP arctic mice
Prion-like
Ibotenic acid
Online Access:https://doi.org/10.1186/2051-5960-2-17

Internet

https://doi.org/10.1186/2051-5960-2-17

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