Safety and effectiveness of HSK21542 for hemodialysis patients: a multiple ascending dose study

Safety and effectiveness of HSK21542 for hemodialysis patients: a multiple ascending dose study

Background: HSK21542, a novel selective peripherally-restricted κ-opioid receptor agonist has been proven to be a safe and effective analgesic and antipruritic drug in both in vitro and in vivo studies. We aimed to evaluate its safety, pharmacokinetics and efficacy in hemodialysis patients over a 1-...

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Bibliographic Details
Main Authors: Mingming Pan, Guihua Wang, Li Zhou, Yan Xu, Li Yao, Chaoqing Wu, Changlin Mei, Zhanzheng Zhao, Dong Sun, Tianjun Guan, Qinkai Chen, Ming Shi, Hui Xu, Weifang Zeng, Fangqiong Li, Rui Yan, Bi-Cheng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Pharmacology
Subjects:
CKD-aP
HSK21542
hemodialysis
κ-opioid receptor agonist
uremic pruritus
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1203642/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1203642/full

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