Identification of a Novel Oncogenic Fusion Gene <i>SPON1-TRIM29</i> in Clinical Ovarian Cancer That Promotes Cell and Tumor Growth and Enhances Chemoresistance in A2780 Cells

Identification of a Novel Oncogenic Fusion Gene <i>SPON1-TRIM29</i> in Clinical Ovarian Cancer That Promotes Cell and Tumor Growth and Enhances Chemoresistance in A2780 Cells

Gene structure alterations, such as chromosomal rearrangements that develop fusion genes, often contribute to tumorigenesis. It has been shown that the fusion genes identified in public RNA-sequencing datasets are mainly derived from intrachromosomal rearrangements. In this study, we explored fusion...

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Bibliographic Details
Main Authors: Saya Nagasawa, Kazuhiro Ikeda, Daisuke Shintani, Chiujung Yang, Satoru Takeda, Kosei Hasegawa, Kuniko Horie, Satoshi Inoue
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
fusion transcript
ovarian cancer
RNA-sequencing
small interfering RNA (siRNA)
xenograft
Online Access:https://www.mdpi.com/1422-0067/23/2/689

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https://www.mdpi.com/1422-0067/23/2/689

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