Kallikrein 5 Inhibition by the Lympho-Epithelial Kazal-Type Related Inhibitor Hinders Matriptase-Dependent Carcinogenesis

Kallikrein 5 Inhibition by the Lympho-Epithelial Kazal-Type Related Inhibitor Hinders Matriptase-Dependent Carcinogenesis

Head and neck squamous cell carcinoma remains challenging to treat with no improvement in survival rates over the past 50 years. Thus, there is an urgent need to discover more reliable therapeutic targets and biomarkers for HNSCC. Matriptase, a type-II transmembrane serine protease, induces malignan...

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Bibliographic Details
Main Authors: Elaine Zayas Marcelino da Silva, Thais Fernanda de Campos Fraga-Silva, Yao Yuan, Márcia Gaião Alves, Gabriel Azevedo Publio, Carol Kobori da Fonseca, Márcio Hideki Kodama, Gabriel Viliod Vieira, Marina Ferreira Candido, Lara Maria Alencar Ramos Innocentini, Mateus Gonçalves Miranda, Alfredo Ribeiro da Silva, Jose Carlos Alves-Filho, Vania Luiza Deperon Bonato, Ramiro Iglesias-Bartolome, Katiuchia Uzzun Sales
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
LEKTI
SPINK5
KLK5
OSCC
matriptase
Online Access:https://www.mdpi.com/2072-6694/13/17/4395

Internet

https://www.mdpi.com/2072-6694/13/17/4395

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