Suppression of the necroptotic cell death pathways improves survival in Smn2B/− mice

Suppression of the necroptotic cell death pathways improves survival in Smn2B/− mice

Spinal muscular atrophy (SMA) is a monogenic neuromuscular disease caused by low levels of the Survival Motor Neuron (SMN) protein. Motor neuron degeneration is the central hallmark of the disease. However, the SMN protein is ubiquitously expressed and depletion of the protein in peripheral tissues...

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Bibliographic Details
Main Authors: Lucia Chehade, Marc-Olivier Deguise, Yves De Repentigny, Rebecca Yaworski, Ariane Beauvais, Sabrina Gagnon, Niko Hensel, Rashmi Kothary
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuroinflammation
necroptosis
motor neuron disease (MND)
multi-system disease
mouse genetic models
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.972029/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2022.972029/full

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