Enantioselective reduction of sulfur-containing cyclic imines through biocatalysis

The 3-thiazolidine ring, a pharmaceutically interesting cyclic structural element found e.g. in some antibiotics, is hard to obtain via currently used approaches. Here, the authors developed a straightforward method to efficiently synthesize a variety of defined, pure 3-thiazolidines.

Bibliographic Details
Main Authors: Nadine Zumbrägel, Christian Merten, Stefan M. Huber, Harald Gröger
Format: Article
Language:English
Published: Nature Portfolio 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03841-5