Reduced Energy Metabolism Impairs T Cell-Dependent B Cell Responses in Patients With Advanced HBV-Related Cirrhosis

Reduced Energy Metabolism Impairs T Cell-Dependent B Cell Responses in Patients With Advanced HBV-Related Cirrhosis

Background and AimsPatients with decompensated HBV-related liver cirrhosis (HBV D-LC) showed compromised immune responses, which manifested as a proneness to develop infections and hyporesponsiveness to vaccines, resulting in accelerated disease progression. The alterations in T cell-dependent B cel...

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Bibliographic Details
Main Authors: Chunhong Huang, Junwei Shao, Congcong Lou, Fengtian Wu, Tiantian Ge, Hainv Gao, Xiaoping Zheng, Xuejun Dong, Lichen Xu, Zhi Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
cirrhosis
B cell
metabolism
OCR
ECAR
mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.660312/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.660312/full

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