Chitosan nanomedicine containing RGD peptide and PAD4 inhibitor based on phenyl boronate coupling inhibition of primary tumor growth and lung metastasis

Chitosan nanomedicine containing RGD peptide and PAD4 inhibitor based on phenyl boronate coupling inhibition of primary tumor growth and lung metastasis

Stimulus-responsive nanodrugs have been extensively studied and their structural changes in the cells are important for controlled intracellular drug release. Histone citrullination of peptidylarginine deiminase 4 (PAD4) regulates the expression of tumor suppressor genes. In our previous study, comp...

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Bibliographic Details
Main Authors: Yijiang Jia, Ayijiang Taledaohan, Renbo Jia, Xin Wang, Yunshu Jia, Jiawang Liu, Yuji Wang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Peptidyl arginine deiminase 4 (PAD4) inhibitors
Phenylboronic acid esters
Oxidative stress responsive nanodrugs
RGD sequence peptides
Tumor immune microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016244

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http://www.sciencedirect.com/science/article/pii/S0753332223016244

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