An Easy Synthesis of Monofluorinated Derivatives of Pyrroles from β-Fluoro-β-Nitrostyrenes

An Easy Synthesis of Monofluorinated Derivatives of Pyrroles from β-Fluoro-β-Nitrostyrenes

The catalyst-free conjugate addition of pyrroles to β-Fluoro-β-nitrostyrenes was investigated. The reaction was found to proceed under solvent-free conditions to form 2-(2-Fluoro-2-nitro-1-arylethyl)-1<i>H</i>-pyrroles. The effectiveness of this approach was demonstrated through the prep...

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Bibliographic Details
Main Authors: Alexander S. Aldoshin, Andrey A. Tabolin, Sema L. Ioffe, Valentine G. Nenajdenko
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
β-Fluoro-β-nitrostyrene
vinylpyrrole
Michael addition
elimination
kinetics
Hammett equation
Online Access:https://www.mdpi.com/1420-3049/26/12/3515

Internet

https://www.mdpi.com/1420-3049/26/12/3515

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