Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity

Abstract Background Metabolic perturbations and slower renewal of cellular components associated with aging increase the risk of Parkinson’s disease (PD). Declining activity of AMPK, a critical cellular energy sensor, may therefore contribute to neurodegeneration. Methods Here, we overexpress variou...

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Bibliographic Details
Main Authors: Wojciech Bobela, Sameer Nazeeruddin, Graham Knott, Patrick Aebischer, Bernard L. Schneider
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Molecular Neurodegeneration
Subjects:
Aging
AMPK
α-synuclein
Neuroprotection
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s13024-017-0220-x

Internet

http://link.springer.com/article/10.1186/s13024-017-0220-x

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