Benzimidazoisoquinoline derivatives inhibit glioblastoma cell proliferation through down-regulating Raf/MEK/ERK and PI3K/AKT pathways

Benzimidazoisoquinoline derivatives inhibit glioblastoma cell proliferation through down-regulating Raf/MEK/ERK and PI3K/AKT pathways

Abstract Background Recent studies showed that benzimidazoleisoquinolinone derivatives exhibit anticancer activity against human cancer cell lines. The aim of this study is to evaluate the anti-tumor effects and mechanisms of benzimidazoleisoquinolinones in isocitrate dehydrogenase-wildtype subtype...

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Bibliographic Details
Main Authors: Ya-Jun Zhang, Zhi-Gang Xu, Shi-Qiang Li, Liu-Jun He, Yan Tang, Zhong-Zhu Chen, Dong-Lin Yang
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Cancer Cell International
Subjects:
Benzimidazoleisoquinolinone
GBM
S phase arrest
Apoptosis
PI3K/Akt pathway
Raf/MEK/ERK pathway
Online Access:http://link.springer.com/article/10.1186/s12935-018-0588-x

Internet

http://link.springer.com/article/10.1186/s12935-018-0588-x

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