Stress-induced PARP activation mediates recruitment of Drosophila Mi-2 to promote heat shock gene expression.
Eukaryotic cells respond to genomic and environmental stresses, such as DNA damage and heat shock (HS), with the synthesis of poly-[ADP-ribose] (PAR) at specific chromatin regions, such as DNA breaks or HS genes, by PAR polymerases (PARP). Little is known about the role of this modification during c...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-07-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3145624?pdf=render |