TSH Signaling Overcomes B-RafV600E–Induced Senescence in Papillary Thyroid Carcinogenesis through Regulation of DUSP6

TSH Signaling Overcomes B-RafV600E–Induced Senescence in Papillary Thyroid Carcinogenesis through Regulation of DUSP6

B-RafV600E oncogene mutation occurs most commonly in papillary thyroid carcinoma (PTC) and is associated with tumor initiation. However, a genetic modification by B-RafV600E in thyrocytes results in oncogene-induced senescence (OIS). In the present study, we explored the factors involved in the sene...

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Bibliographic Details
Main Authors: Young Hwa Kim, Yong Won Choi, Jae Ho Han, Jeonghun Lee, Euy Young Soh, So Hyun Park, Jang-Hee Kim, Tae Jun Park
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558614001614

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http://www.sciencedirect.com/science/article/pii/S1476558614001614

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