Cross-study safety analysis of risk factors in CAR T cell clinical trials: An FDA database pilot project

Cross-study safety analysis of risk factors in CAR T cell clinical trials: An FDA database pilot project

The Chimeric Antigen Receptor (CAR) T Cell Safety Database Project explored the use of cross-study safety data to identify risk factors associated with severe cytokine release syndrome (sCRS) and severe neurological toxicities (sNTX) after CAR T cell administration. Sponsors voluntarily submitted da...

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Bibliographic Details
Main Authors: Matthew Foster, Yonatan Negash, Leslie Eberhardt, Wilson W. Bryan, Kimberly Schultz, Xiaofei Wang, Yuan Xu, Bindu George
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
chimeric antigen receptor (CAR) T cells
cytokine release syndrome
neurological toxicity
CD19
BCMA
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522001280

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http://www.sciencedirect.com/science/article/pii/S2372770522001280

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