A Single V672F Substitution in the Spike Protein of Field-Isolated PEDV Promotes Cell–Cell Fusion and Replication in VeroE6 Cells

A Single V672F Substitution in the Spike Protein of Field-Isolated PEDV Promotes Cell–Cell Fusion and Replication in VeroE6 Cells

While porcine epidemic diarrhea virus (PEDV) infects and replicates in enterocytes lining villi of neonatal piglets with high efficiency, naturally isolated variants typically grow poorly in established cell lines, unless adapted by multiple passages. Cells infected with most cell-adapted PEDVs usua...

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Bibliographic Details
Main Authors: Asawin Wanitchang, Janya Saenboonrueng, Challika Kaewborisuth, Kanjana Srisutthisamphan, Anan Jongkaewwattana
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Viruses
Subjects:
PEDV
spike
cell–cell fusion
syncytium
chimeric proteins
receptor preference
Online Access:https://www.mdpi.com/1999-4915/11/3/282

Internet

https://www.mdpi.com/1999-4915/11/3/282

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