Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages

Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages

Abstract Recent studies reported that Methyl-CpG–binding domain protein 2 (MBD2) promoted M2 macrophages accumulation to increase bleomycin-induced pulmonary fibrosis. However, the role and mechanism of action of MBD2 in macrophages differentiation and renal fibrosis remain largely unknown. In the c...

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Bibliographic Details
Main Authors: Kai Ai, Jian Pan, Pan Zhang, Huiling Li, Zhibiao He, Hongliang Zhang, Xiaozhou Li, Yijian Li, Lei Yi, Ye Kang, Yinhuai Wang, Xudong Xiang, Xiangping Chai, Dongshan Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2022-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04577-3

Internet

https://doi.org/10.1038/s41419-022-04577-3

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