Overexpression of Wnt5a promoted the protective effect of mesenchymal stem cells on Lipopolysaccharide-induced endothelial cell injury via activating PI3K/AKT signaling pathway

Overexpression of Wnt5a promoted the protective effect of mesenchymal stem cells on Lipopolysaccharide-induced endothelial cell injury via activating PI3K/AKT signaling pathway

Abstract Background Lung endothelial barrier injury plays an important role in the pathophysiology of acute lung injury/acute respiratory distress syndrome (ALI/ARDS). Mesenchymal stem cells (MSCs) therapy has shown promise in ARDS treatment and restoration of the impaired barrier function. It has b...

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Bibliographic Details
Main Authors: Manliang Guo, Shiqi Li, Chuan Li, Xueyan Mao, Liru Tian, Xintong Yang, Caixia Xu, Mian Zeng
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Infectious Diseases
Subjects:
Wnt5a
Mesenchymal stem cells
Endothelial cell injury
Acute lung injury
PI3K/AKT signaling
Online Access:https://doi.org/10.1186/s12879-024-09204-4

Internet

https://doi.org/10.1186/s12879-024-09204-4

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