An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

Monocyte counts are increased during human tuberculosis (TB) but it has not been determined whether Mycobacterium tuberculosis (Mtb) directly regulates myeloid commitment. We demonstrated that exposure to Mtb directs primary human CD34+ cells to differentiate into monocytes/macrophages. In vitro mye...

Full description

Bibliographic Details
Main Authors: Murilo Delgobo, Daniel AGB Mendes, Edgar Kozlova, Edroaldo Lummertz Rocha, Gabriela F Rodrigues-Luiz, Lucas Mascarin, Greicy Dias, Daniel O Patrício, Tim Dierckx, Maíra A Bicca, Gaëlle Bretton, Yonne Karoline Tenório de Menezes, Márick R Starick, Darcita Rovaris, Joanita Del Moral, Daniel S Mansur, Johan Van Weyenbergh, André Báfica
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
Mycobacterium
tuberculosis
interferons
interleukins
evolution
human
Online Access:https://elifesciences.org/articles/47013

Internet

https://elifesciences.org/articles/47013

Similar Items