An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans

Monocyte counts are increased during human tuberculosis (TB) but it has not been determined whether Mycobacterium tuberculosis (Mtb) directly regulates myeloid commitment. We demonstrated that exposure to Mtb directs primary human CD34+ cells to differentiate into monocytes/macrophages. In vitro mye...

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Detalles Bibliográficos
Autores principales: Murilo Delgobo, Daniel AGB Mendes, Edgar Kozlova, Edroaldo Lummertz Rocha, Gabriela F Rodrigues-Luiz, Lucas Mascarin, Greicy Dias, Daniel O Patrício, Tim Dierckx, Maíra A Bicca, Gaëlle Bretton, Yonne Karoline Tenório de Menezes, Márick R Starick, Darcita Rovaris, Joanita Del Moral, Daniel S Mansur, Johan Van Weyenbergh, André Báfica
Formato: Artículo
Lenguaje:English
Publicado: eLife Sciences Publications Ltd 2019-10-01
Colección:eLife
Materias:
Mycobacterium
tuberculosis
interferons
interleukins
evolution
human
Acceso en línea:https://elifesciences.org/articles/47013

Internet

https://elifesciences.org/articles/47013

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