Pyruvate protects against experimental stroke via an anti-inflammatory mechanism

Pyruvate, a key intermediate in glucose metabolism, was explored as a potential treatment in models of experimental stroke and inflammation. Pyruvate was administered to rodents after the onset of middle cerebral artery occlusion (MCAO). Since the extent of inflammation is often proportional to the...

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Bibliographic Details
Main Authors: Qing Wang, Michael van Hoecke, Xian Nan Tang, Hokyou Lee, Zheng Zheng, Raymond A. Swanson, Midori A. Yenari
Format: Article
Language:English
Published: Elsevier 2009-10-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001879