Application of the Adverse Outcome Pathway Concept to In Vitro Nephrotoxicity Assessment: Kidney Injury due to Receptor-Mediated Endocytosis and Lysosomal Overload as a Case Study

Application of the Adverse Outcome Pathway Concept to In Vitro Nephrotoxicity Assessment: Kidney Injury due to Receptor-Mediated Endocytosis and Lysosomal Overload as a Case Study

Application of adverse outcome pathways (AOP) and integration of quantitative in vitro to in vivo extrapolation (QIVIVE) may support the paradigm shift in toxicity testing to move from apical endpoints in test animals to more mechanism-based in vitro assays. Here, we developed an AOP of proximal tub...

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Bibliographic Details
Main Authors: Sebastian Jarzina, Stefano Di Fiore, Bernhard Ellinger, Pia Reiser, Sabrina Frank, Markus Glaser, Jiaqing Wu, Femke J. Taverne, Nynke I. Kramer, Angela Mally
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Toxicology
Subjects:
adverse outcome pathway (AOP)
nephrotoxicity
In vitro toxicity testing
QIVIVE
risk assessment
key event relationship
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2022.864441/full

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https://www.frontiersin.org/articles/10.3389/ftox.2022.864441/full

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