Glycation Interferes with the Activity of the Bi-Functional UDP-<i>N</i>-Acetylglucosamine 2-Epimerase/<i>N</i>-Acetyl-mannosamine Kinase (GNE)

Glycation Interferes with the Activity of the Bi-Functional UDP-<i>N</i>-Acetylglucosamine 2-Epimerase/<i>N</i>-Acetyl-mannosamine Kinase (GNE)

Mutations in the gene coding for the bi-functional UDP-<i>N</i>-acetylglucosamine 2-epimerase/<i>N</i>-acetylmannosamine kinase (GNE), the key enzyme of the sialic acid biosynthesis, are responsible for autosomal-recessive GNE myopathy (GNEM). GNEM is an adult-onset disease w...

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Bibliographic Details
Main Authors: Vanessa Hagenhaus, Jacob L. Gorenflos López, Rebecca Rosenstengel, Carolin Neu, Christian P. R. Hackenberger, Arif Celik, Klara Weinert, Mai-Binh Nguyen, Kaya Bork, Rüdiger Horstkorte, Astrid Gesper
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomolecules
Subjects:
GNE-myopathy
glycation
methylglyoxal
sialylation
post-translational modification
adult-onset disease
Online Access:https://www.mdpi.com/2218-273X/13/3/422

Internet

https://www.mdpi.com/2218-273X/13/3/422

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