Glycation Interferes with the Activity of the Bi-Functional UDP-<i>N</i>-Acetylglucosamine 2-Epimerase/<i>N</i>-Acetyl-mannosamine Kinase (GNE)
Mutations in the gene coding for the bi-functional UDP-<i>N</i>-acetylglucosamine 2-epimerase/<i>N</i>-acetylmannosamine kinase (GNE), the key enzyme of the sialic acid biosynthesis, are responsible for autosomal-recessive GNE myopathy (GNEM). GNEM is an adult-onset disease w...
Main Authors: | Vanessa Hagenhaus, Jacob L. Gorenflos López, Rebecca Rosenstengel, Carolin Neu, Christian P. R. Hackenberger, Arif Celik, Klara Weinert, Mai-Binh Nguyen, Kaya Bork, Rüdiger Horstkorte, Astrid Gesper |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-02-01
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Series: | Biomolecules |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-273X/13/3/422 |
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