ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response

ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response

Activation of the unfolded protein response (UPR) sustains protein homeostasis (proteostasis) and plays a fundamental role in tissue maintenance and longevity of organisms. Long-range control of UPR activation has been demonstrated in invertebrates, but such mechanisms in mammals remain elusive. Her...

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Bibliographic Details
Main Authors: Richard H Chapple, Tianyuan Hu, Yu-Jung Tseng, Lu Liu, Ayumi Kitano, Victor Luu, Kevin A Hoegenauer, Takao Iwawaki, Qing Li, Daisuke Nakada
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
Hematopoietic stem cells
unfolded protein response
estrogen
regeneration
irradiation
Ire1
Online Access:https://elifesciences.org/articles/31159

Internet

https://elifesciences.org/articles/31159

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